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F. Lippert, R.M. Buch, S.M. Wetterer, C. González-Cabezas Summary: NaF dentifrices showed greater efficacy than MEP at promoting enamel fluoride uptake and early caries lesion remineralization as well as diminishing subsequent demineralization.
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F. Lippert, M.R. Buch, R.J. Gambogi, S.M. Wetterer, C. Gonzonzález-Cabezas, B.R. Schemehorn. Summary: NaF pastes delivered more fluoride & faster into enamel than MFP pastes.
E.E. Newby, C.S. Newby, G.D. Wood and B.R. Schemehorn. Summary: NaF dentifrices were significantly more efficient in the promotion of demineralization, prevention of demineralization and enamel fluoride uptake in comparison to MFP dentrifices. Furthermore, significant differences in these processes were observed between two NaF formulations with similar available fluoride.
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L.A. Stockert, M.L. Bosma, H.M. Proskin, C.J. Kleber and K.R. Milleman Summary: All three products tested produced statistically significant whole mouth tooth whitening compared with baseline after 5 days and 7 days of treatment and had a similar AE profile.
K.R. Milleman, J.L. Milleman, C.J. Kleber, M.L. Bosma, and H.M. Proskin Summary: Placement of a 9% w/w hydrogen peroxide bleaching gel resulted in observable tooth whitening from the facial surface on specific treated and adjacent untreated areas. There was no treatment-emergent oral soft tissue irritation or tooth sensitivity.
J. Gordon and E. Paterson Summary: This simple and rapid in vitro model provides a good method for evaluating bleaching performance of an experimental tooth whitening system containing hydrogen peroxide. The substantivity challenge incorporated into this model provided a realistic challenge to these treatments.
E.E. Newby, L.A. Stockert, M.L. Bosma, M. North, and J. Liebman Summary: Degradation of hydrogen peroxide on the gingiva and teeth decreased over time. Low salivary peroxide levels indicated minimal systemic exposure to hydrogen peroxide from saliva. Substantial levels of hydrogen peroxide remained on the teeth through 60 minutes that could be delivered to the teeth.
Bordas, M.L. Bosma, C.J. Kleber, K. Milleman, J. Milleman, N. Schober,and G. Shanga Summary: Carbopol/silica gel formulation demonstrated a similar safety profile to Carbopol hydrogen peroxide gel formulations (10.5% and 11.2%) and had a lower incidence of oral findings.
A. Hunt, F. Lippert, and C. González-Cabezas Summary: Consistent with published literature, experimental tooth whitening system showed no significant effects on human enamel hardness and morphology.
L.A. Stockert, K. Bauroth, M.L. Bosma and A. Selmani Summary: The experimental tooth whitening system produced observable whitening after 3 days and statistically significant tooth shade reductions after 5 days and 7 days.
D. Zero, H.M. Proskin, R.M. Buch, C. Kollar, M.L. Bosma, and S.R. Smith Summary: A dentifrice containing 1350 ppm F from sodium fluoride/silica base had significantly greater enamel fluoride uptake and remineralization potential than a dentifrice containing a combination of 1000 ppm F from sodium monofluorophosphate and 450 ppm F from sodium fluoride in a dicalcium phosphate base. A dose response was demonstrated by sodium fluoride dentifrices.
F.G. Saunders, M.L. Bosma, R.M. Buch, C.M. Kollar, E.A. Martinez-Mier, D. Zero Summary: All fluoride toothpastes in this study showed increases in plaque fluid fluoride levels from baseline and were directionally better than the control at all time points, with the exception of Aim at 4 hours. Plaque fluid fluoride levels for the NaF treatments (Crest and Colgate) were directionally better than Aim, which contains NaMFP.
J. Parry, R. McNab, J. Creeth, F. Lippert, and A.J. Smith Summary: The susceptibility of human and bovine enamel to both erosion and abrasion was comparable, although bovine enamel may be more susceptible to abrasion following erosive wear. Bovine enamel produced a glossier surface compared with human enamel following abrasion alone and following both an erosive and abrasive challenge. Bovine enamel may offer a suitable alternative substrate for tooth wear research.
G.R. Burnett, E.L Macdonald, M. Addy, and R. McNab Summary: Published in vitro models that focus on stain prevention use powdered hydroxyapatite4,5 as a substrate, which is difficult to handle and poses problems when trying to quantify stain prevention. The new hydroxyapatite assay for stain prevention (HASP) plate model has proven to be a useful and convenient tool for evaluating the potential for a material to prevent staining and quantifying this effect via spectroscopic measurements.
X. Shi, R.C. Emling, J. Smith, and S.L. Yankell Summary: The mean interproximal access efficacy values, using horizontal or vertical brushing, on anterior or posterior teeth, as well as the overall mean, were significantly higher (p< 0.001) for the new prototype product than the commercially available toothbrush.
J. Bowman, S. Shirodaria, A. Gallagher, J. Krawczuk, and D. Hamlin Summary: Detailed analysis of the subject populations indicated a similar profile of usage of xerostomic concomitant medications across the three different geographic and demographic population bases. The most frequently used medications were for hypertension, cholesterol and anxiety. 85% of subjects were on polypharmacy, taking more than one xerostomia inducing-medication. This confirms a need for more efficacious therapies.
A.P. Barlow, C. Parkinson, A. Butler, S.C. Mason, M. Addy, and N. West Summary: This in situ method combining scanning electron microscopy replica analysis was shown to differentiate successfully between a recognized occluding antisensitivity toothpaste and nonoccluding control, providing a valuable new in situ methodology for determining tubule patency.
C. Fowler, C. Newby, G. Rees, and A. Brown Summary: Treatment of human enamel erosive lesions with fluoride-containing toothpastes leads to penetration of fluoride into the surface of the enamel. Fluoride penetration was 40–150% greater for the pastes containing NaF alone or NaF and KNO3, compared with those based on AmF, SnF2, or NaF plus sodium pyrophosphate.
C.R. Parkinson and A. Sasov Summary: Individual dentine tubules have been visualised and interrogated nondestructively using ultrahigh-resolution X-ray CT for the first time. A point of paramount significant for designing tailored antisensitivity actives.
E. Shen and S. Wetterer Summary: A novel in vitro method for staining on denture acrylic was developed, allowing for differentiation of cleaning efficacy.
C.J. Kleber, J.L. Milleman, M.H. Moore, P.M. Fernandez, S. Sykes, and G.M. Shanga Summary: Both the cleansing foam and the soaking tablet solution did not cause surface abrasion and loss of gloss after 90 minutes of hand-brushing, and were not significantly different from each other at all time points. The conventional dentifrice caused surface abrasion and loss of gloss, and was statistically different from the other two denture cleansers.
S.M. Wetterer, S. Aggour, P. Stern, and S. Lech Summary: Edentulous patients were able to effectively communicate self-perception of cleanliness. Perception of breath cleanliness and denture cleanliness correlated strongly and could be markedly improved for extended periods of time by denture cleanser application.